ER to Golgi ceramide transport

Across TCGA pan-cancer cohorts, RNA activity of the ER to Golgi ceramide transport pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ER to Golgi ceramide transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and PAAD, show the opposite pattern, with higher activity associated with better survival.

CESC, LIHC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	All	0.805	0.935	<.001	94	view →
LIHC	OS	Median	All	0.569	0.760	<.001	86	view →
MESO	OS	Quartile	All	0.336	0.638	.001	77	view →
LUSC	OS	Quartile	III,IV	0.503	0.855	<.001	56	view →
HNSC	OS	Tertile	III,IV	0.654	0.782	.003	49	view →
BRCA	OS	Median	III,IV	0.753	0.903	<.001	43	view →
LGG	DFS	Median	All	0.305	0.460	<.001	38	view →
KIRC	OS	Tertile	All	0.541	0.677	.002	36	view →
BLCA	DFS	Median	All	0.445	0.694	<.001	29	view →
KIRP	DFS	Quartile	II,III,IV	0.302	1.000	.008	20	view →
READ	OS	Median	III,IV	0.737	0.308	.003	19	view →
LUAD	OS	Quartile	All	0.276	0.496	.004	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0035621–CESC (OS)

Open the CESC breakdown →