Positive regulation of chromatin binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of chromatin binding pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL12_S38, TIMELESS_S1173, and WDR43_S77, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromatin binding activity versus RPL12_S38 in LUAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL12_S38 →	+0.744	+0.074	<.001	<.001	3	8
HNSC	TIMELESS_S1173 →	+0.574	+0.075	<.001	<.001	3	8
LUAD	WDR43_S77 →	+0.542	+0.072	<.001	<.001	3	8
PDAC	ESF1_S153 →	+0.801	+0.065	<.001	<.001	3	8
GBM	HAT1 →	+0.324	+0.036	.002	.005	3	8
UCEC	LIG1 →	+0.386	+0.069	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035563 vs RPL12_S38 — LUAD

Explore this scatter interactively →