Positive regulation of chromatin binding

Across TCGA patient cohorts, RNA activity of the Positive regulation of chromatin binding pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTX3L, DDX58, and RTP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of chromatin binding activity versus DTX3L in LSCC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DTX3L →	+0.724	+0.521	<.001	<.001	3	5
LSCC	DDX58 →	+0.754	+0.423	<.001	.002	3	3
HNSC	RTP4 →	+0.993	+0.186	.008	.001	3	3
LSCC	SAMD9 →	+0.977	+0.521	<.001	.003	3	3
HNSC	IFIH1 →	+0.651	+0.161	.003	<.001	3	3
HNSC	IFIT3 →	+1.097	+0.136	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035563 vs DTX3L — LSCC

Explore this scatter interactively →