Positive regulation of chromatin binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromatin binding pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF9, UBE2L6, and NDUFS7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IRF9 grouped by Positive regulation of chromatin binding-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IRF9 →	-1.539	-1.017	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	UBE2L6 →	-1.377	-0.928	.004	.001	3	4
OESOPHAGUS	NDUFS7 →	+0.679	+0.817	.001	.007	3	4
KIDNEY	AJUBA →	-0.781	-0.936	.001	.002	3	4
KIDNEY	CYLD →	-0.737	-0.844	.006	.006	3	4
PANCREAS	TAF4B →	+0.863	+1.412	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IRF9 by Positive regulation of chromatin binding activity — SKIN

Explore this box plot interactively →