Positive regulation of chromatin binding

Across TCGA cell cohorts, RNA activity of the Positive regulation of chromatin binding pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PORCN, LILRB1, and SNX25, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PORCN grouped by Positive regulation of chromatin binding-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PORCN →	+0.276	+0.456	.004	.009	3	1
BREAST	LILRB1 →	-0.167	-0.378	.006	.006	3	1
BREAST	SNX25 →	-0.375	-0.378	.006	.006	3	1
BREAST	CLK4 →	-0.180	-0.378	.005	.006	3	1
BREAST	IL4 →	-0.159	-0.378	.002	.006	3	1
BREAST	PIK3C2A →	+0.345	+0.378	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PORCN by Positive regulation of chromatin binding activity — BREAST

Explore this box plot interactively →