Regulation of SNARE complex assembly

Across TCGA cell cohorts, RNA activity of the Regulation of SNARE complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CUTA, TMEM191B, and VPS29, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of SNARE complex assembly activity versus CUTA in SOFT_TISSUE (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CUTA →	+1.123	+0.476	.007	<.001	2	5
BLOOD_Myeloma	TMEM191B →	+0.657	+0.450	.009	.002	3	4
LUNG_SCLC	VPS29 →	+0.584	+0.879	.002	.001	3	4
LUNG_SCLC	AMD1 →	-0.425	-0.798	.001	.003	3	4
LUNG_SCLC	ADAMTS14 →	+1.869	+1.079	<.001	.001	3	4
LUNG_SCLC	TMSB15B →	+1.903	+0.720	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035542 vs CUTA — SOFT_TISSUE

Explore this scatter interactively →