Vitamin transmembrane transport

Across TCGA cell cohorts, RNA activity of the Vitamin transmembrane transport pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC19A3, AGAP4, and CTAGE1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC19A3 grouped by Vitamin transmembrane transport-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC19A3 →	-0.220	-0.744	.001	.003	3	7
KIDNEY	AGAP4 →	-0.227	-0.553	.009	.003	3	4
BLOOD_Myeloma	CTAGE1 →	-0.422	-1.574	<.001	.001	3	4
BLOOD_Leukemia	DUSP23 →	-0.161	-1.036	.003	.001	3	4
SKIN	PSMA3 →	-0.316	-0.783	<.001	.001	3	4
SKIN	GOPC →	-0.175	-0.913	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC19A3 by Vitamin transmembrane transport activity — SKIN

Explore this box plot interactively →