Vitamin transmembrane transport

Across TCGA cell cohorts, RNA activity of the Vitamin transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP16, TRIAP1, and CARD16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP16 grouped by Vitamin transmembrane transport-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DUSP16 →	-0.810	-0.495	.001	.001	3	4
URINARY_TRACT	TRIAP1 →	-0.863	-1.523	.001	<.001	3	4
STOMACH	CARD16 →	+2.585	+1.088	.001	.009	3	4
LUNG_SCLC	S1PR5 →	+1.811	+1.472	.001	.004	3	4
BREAST	CST3 →	-2.435	-0.684	.002	.008	3	3
KIDNEY	BMP8B →	-1.280	-0.738	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP16 by Vitamin transmembrane transport activity — KIDNEY

Explore this box plot interactively →