Response to interferon-beta

Across TCGA patient cohorts, RNA activity of the Response to interferon-beta pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAS2, SP110, and IFI44L, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interferon-beta activity versus OAS2 in HNSC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OAS2 →	+1.457	+0.163	<.001	<.001	3	8
HNSC	SP110 →	+0.905	+0.163	<.001	<.001	3	8
HNSC	IFI44L →	+1.687	+0.177	<.001	<.001	3	8
HNSC	PARP9 →	+0.789	+0.171	<.001	<.001	3	8
HNSC	IFI35 →	+1.103	+0.148	<.001	<.001	3	8
GBM	OAS3 →	+1.193	+0.239	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035456 vs OAS2 — HNSC

Explore this scatter interactively →