Positive regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDUFA3P1, SETP10, and TLCD4-RWDD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peroxisome proliferator activated receptor signaling pathway activity versus NDUFA3P1 in HNSC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NDUFA3P1 →	+0.585	+0.580	.003	.001	3	3
UCEC	SETP10 →	+0.584	+0.673	.006	.003	2	4
PDAC	TLCD4-RWDD3 →	+0.203	+0.404	.001	<.001	3	3
BRCA	MCL1 →	-0.514	-0.724	.001	.001	3	3
LUAD	SALRNA1 →	+0.875	+0.539	<.001	.002	3	3
COAD	ASPHD1 →	-0.535	-0.583	.004	.004	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035360 vs NDUFA3P1 — HNSC

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