Positive regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of peroxisome proliferator activated receptor signaling pathway pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in lung adenocarcinoma (LUAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LUAD and LUSC, show the opposite pattern, with lower activity in tumor tissue.

LUAD, LUSC, and BRCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LUAD	Male	All	−0.127	<.001	9	view →
LUSC	Male	II,III,IV	−0.153	<.001	8	view →
BRCA	All	III,IV	−0.131	<.001	6	view →
KICH	All	All	−0.041	<.001	6	view →
BLCA	Male	All	−0.054	.012	5	view →
COAD	All	All	−0.028	.005	5	view →
UCEC	All	All	−0.057	.002	2	view →
READ	Female	All	−0.073	.015	1	view →
STAD	All	All	−0.035	.029	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0035360–LUAD

Open the LUAD breakdown →