Positive regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR33_S1210, XRCC1_S226, and EZH1_S416, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peroxisome proliferator activated receptor signaling pathway activity versus WDR33_S1210 in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WDR33_S1210 →	+0.578	+0.611	<.001	<.001	3	4
UCEC	XRCC1_S226 →	+0.426	+0.740	<.001	<.001	3	3
UCEC	EZH1_S416 →	-0.897	-0.967	<.001	<.001	3	3
BRCA	NUP98_S888 →	+0.664	+1.080	<.001	<.001	3	3
LSCC	ARID4B_S1153 →	+0.508	+0.937	<.001	<.001	3	3
UCEC	TP53INP2_S14 →	+1.462	+2.084	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035360 vs WDR33_S1210 — GBM

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