Positive regulation of peroxisome proliferator activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A3, SNRNP40, and CPNE7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peroxisome proliferator activated receptor signaling pathway activity versus SLC25A3 in OVARY (Pearson r = 0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SLC25A3 →	+0.639	+1.852	.008	.004	3	5
URINARY_TRACT	SNRNP40 →	+0.404	+2.322	.007	<.001	3	5
LARGE_INTESTINE	CPNE7 →	+2.641	+1.478	.003	.006	3	4
BLOOD_Leukemia	YPEL4 →	-1.225	-0.152	.005	.002	3	4
LARGE_INTESTINE	MRPL16 →	+0.935	+1.544	.004	.008	3	4
BLOOD_Lymphoma	AHNAK →	-5.417	-0.389	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035360 vs SLC25A3 — OVARY

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