Peroxisome proliferator activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SH3BGRL, SEPTIN4_S432, and SF3B1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome proliferator activated receptor signaling pathway activity versus SH3BGRL in LSCC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SH3BGRL →	+0.390	+0.076	<.001	<.001	3	6
BRCA	SEPTIN4_S432 →	+0.578	+0.053	<.001	<.001	3	6
LSCC	SF3B1 →	-0.251	-0.076	<.001	<.001	3	6
GBM	SMC2 →	-0.522	-0.056	.001	.001	3	6
BRCA	BGN →	+0.745	+0.057	<.001	<.001	3	6
BRCA	BTD →	+0.373	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035357 vs SH3BGRL — LSCC

Explore this scatter interactively →