Peroxisome proliferator activated receptor signaling pathway

Across TCGA pan-cancer cohorts, RNA activity of the Peroxisome proliferator activated receptor signaling pathway pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 23 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher Peroxisome proliferator activated receptor signaling pathway pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and READ, show the opposite pattern, with higher activity associated with better survival.

CESC, LUSC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Quartile	III,IV	0.563	0.849	.020	36	view →
LUSC	DFS	Median	III,IV	0.151	0.822	<.001	36	view →
KIRP	OS	Quartile	III,IV	0.356	0.778	.001	34	view →
LGG	OS	Median	All	0.338	0.504	<.001	29	view →
LIHC	OS	Quartile	All	0.419	0.599	.012	18	view →
ACC	DFS	Tertile	III,IV	0.080	0.426	.006	17	view →
STAD	DFS	Tertile	IV	0.246	0.805	.041	12	view →
SARC	DFS	Median	All	0.231	0.483	<.001	11	view →
THCA	DFS	Tertile	III,IV	0.617	0.871	.021	10	view →
CHOL	OS	Tertile	All	0.279	0.831	.008	9	view →
SCLC	DFS	Quartile	III,IV	0.756	0.311	.004	8	view →
READ	OS	Quartile	II,III,IV	0.835	0.379	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0035357–CESC (OS)

Open the CESC breakdown →