Peroxisome proliferator activated receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOSL1, PKM, and RALB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome proliferator activated receptor signaling pathway activity versus FOSL1 in BRCA (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FOSL1 →	-0.995	-0.676	.001	.001	3	5
LSCC	PKM →	-0.438	-0.542	.007	.007	3	5
HNSC	RALB →	-0.581	-0.270	.001	.003	3	4
BRCA	ANXA2 →	-0.567	-0.456	<.001	.002	3	4
BRCA	ANXA2P2 →	-0.739	-0.477	.002	.001	3	4
LSCC	ARNTL2 →	-0.915	-0.687	.009	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035357 vs FOSL1 — BRCA

Explore this scatter interactively →