Peroxisome proliferator activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM209, TRIM56, and SEC16B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM209 grouped by Peroxisome proliferator activated receptor signaling pathway-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TMEM209 →	+0.736	+0.673	.005	.007	3	4
PANCREAS	TRIM56 →	-0.694	-0.939	<.001	.005	3	3
OVARY	SEC16B →	-0.701	-0.744	.003	.009	3	3
OVARY	SQOR →	-2.175	-1.040	<.001	.002	3	3
OVARY	TRNAU1AP →	-0.660	-0.935	.001	.006	3	3
OVARY	AHNAK2 →	-1.838	-0.953	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM209 by Peroxisome proliferator activated receptor signaling pathway activity — KIDNEY

Explore this box plot interactively →