Peroxisome proliferator activated receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Peroxisome proliferator activated receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMG9, ERCC1, and RBM33, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peroxisome proliferator activated receptor signaling pathway activity versus SMG9 in OESOPHAGUS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SMG9 →	+1.264	+0.355	.004	<.001	3	6
SKIN	ERCC1 →	+0.855	+0.204	.004	.001	3	5
OESOPHAGUS	RBM33 →	+1.004	+0.388	.006	.003	3	5
BREAST	ATF2 →	+0.783	+0.223	.002	.001	3	5
OESOPHAGUS	MRE11 →	+0.831	+0.263	.005	.003	3	4
OESOPHAGUS	ATP6V0A1 →	+0.949	+0.356	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035357 vs SMG9 — OESOPHAGUS

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