Negative regulation of dephosphorylation

Across TCGA cell cohorts, RNA activity of the Negative regulation of dephosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MASTL, PPP1R8, and URI1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MASTL grouped by Negative regulation of dephosphorylation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MASTL →	-0.655	-1.553	<.001	<.001	2	8
BREAST	PPP1R8 →	-0.227	-0.631	<.001	.002	3	6
BLOOD_Myeloma	URI1 →	-0.664	-1.740	.003	.001	3	6
STOMACH	MED20 →	-0.368	-1.340	.005	.007	3	6
BREAST	SH3GLB2 →	+0.168	+0.868	.009	.004	3	5
SKIN	NIN →	-0.122	-0.525	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MASTL by Negative regulation of dephosphorylation activity — STOMACH

Explore this box plot interactively →