miRNA-mediated gene silencing by mRNA destabilization

Across TCGA patient cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTGES3_S151, CEP170B_S1135, and SART3_S797, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by mRNA destabilization activity versus PTGES3_S151 in HNSC (Pearson r = 0.12).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PTGES3_S151 →	+1.414	+0.141	<.001	.007	3	4
UCEC	CEP170B_S1135 →	+0.439	+0.150	.002	.003	3	3
LUAD	SART3_S797 →	-0.858	-0.061	.002	.006	3	3
PDAC	PPFIBP1_S794 →	-0.381	-0.034	<.001	.001	3	3
OV	ZNF777_S604 →	+0.921	+0.021	.005	.007	3	3
OV	DDX20_S48 →	+0.810	+0.039	.002	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035279 vs PTGES3_S151 — HNSC

Explore this scatter interactively →