miRNA-mediated gene silencing by mRNA destabilization

Across TCGA pan-cancer cohorts, RNA activity of the miRNA-mediated gene silencing by mRNA destabilization pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 51 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher miRNA-mediated gene silencing by mRNA destabilization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and SCLC, show the opposite pattern, with higher activity associated with better survival.

CESC, BLCA, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Quartile	III,IV	0.466	0.905	.001	104	view →
BLCA	OS	Quartile	III,IV	0.209	0.505	.001	51	view →
UVM	DFS	Tertile	III,IV	1.000	0.326	.001	49	view →
SCLC	DFS	Median	III,IV	0.722	0.316	.001	43	view →
LUSC	DFS	Median	All	0.493	0.300	<.001	35	view →
OV	OS	Quartile	All	0.259	0.382	.020	26	view →
DLBC	DFS	Tertile	IV	0.145	1.000	.017	15	view →
MESO	OS	Tertile	IV	0.806	0.301	.004	15	view →
BRCA	DFS	Tertile	III,IV	0.344	0.597	.004	13	view →
COAD	DFS	Tertile	All	0.859	0.708	.004	13	view →
LIHC	DFS	Median	All	0.627	0.503	.018	13	view →
SKCM	DFS	Quartile	All	0.552	0.688	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0035279–CESC (OS)

Open the CESC breakdown →