miRNA-mediated gene silencing by inhibition of translation

Across TCGA patient cohorts, RNA activity of the miRNA-mediated gene silencing by inhibition of translation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VGLL4, FRMD6_S544, and STRN3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by inhibition of translation activity versus VGLL4 in GBM (Pearson r = 0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	VGLL4 →	+0.241	+0.027	.001	<.001	3	4
BRCA	FRMD6_S544 →	+0.534	+0.017	<.001	.004	3	4
UCEC	STRN3 →	+0.168	+0.119	<.001	.007	3	4
UCEC	AHNAK2 →	+0.484	+0.125	.002	.004	3	4
UCEC	KANK2 →	+0.411	+0.083	.003	.007	3	4
UCEC	MITF →	+0.359	+0.135	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035278 vs VGLL4 — GBM

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