miRNA-mediated gene silencing by inhibition of translation

Across TCGA pan-cancer cohorts, RNA activity of the miRNA-mediated gene silencing by inhibition of translation pathway differs between tumor and matched normal tissue in 9 of the 18 cancer types tested.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as BLCA and STAD, show the opposite pattern, with lower activity in tumor tissue.

BLCA, KIRC, and KIRP show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
BLCA	All	III,IV	−0.033	.005	7	view →
KIRC	All	All	+0.019	<.001	7	view →
KIRP	All	IV	+0.045	.015	4	view →
COAD	Female	All	+0.042	<.001	4	view →
STAD	All	All	−0.029	.002	4	view →
READ	All	III,IV	−0.025	.037	2	view →
KICH	Female	III,IV	−0.049	.003	1	view →
ESCA	All	All	−0.047	.027	1	view →
HNSC	All	IV	−0.020	.026	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 9 strongest of 9 lineages.

GO:0035278–BLCA

Open the BLCA breakdown →