miRNA-mediated gene silencing by inhibition of translation

Across TCGA pan-cancer cohorts, RNA activity of the miRNA-mediated gene silencing by inhibition of translation pathway is associated with patient survival in 19 of 34 cancer lineages. Pathway activity is summarized from the expression of its 83 member genes.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher miRNA-mediated gene silencing by inhibition of translation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and SCLC, show the opposite pattern, with higher activity associated with better survival.

CESC, COAD, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	II,III,IV	0.596	0.858	.001	38	view →
COAD	DFS	Quartile	All	0.839	0.670	.003	34	view →
SCLC	DFS	Tertile	III,IV	0.585	0.203	.003	30	view →
BRCA	DFS	Quartile	III,IV	0.698	0.911	.001	26	view →
BLCA	OS	Median	IV	0.221	0.535	.006	22	view →
UVM	DFS	Tertile	III,IV	0.860	0.308	.009	19	view →
KICH	OS	Median	III,IV	0.426	0.920	.003	18	view →
KIRC	DFS	Quartile	III,IV	0.693	0.818	.005	16	view →
DLBC	OS	Median	III,IV	0.272	1.000	.017	12	view →
SKCM	DFS	Tertile	III,IV	0.150	0.330	.008	11	view →
CHOL	DFS	Quartile	All	0.132	0.517	.004	9	view →
ESCA	DFS	Median	All	0.460	0.607	.013	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

GO:0035278–CESC (DFS)

Open the CESC breakdown →