miRNA-mediated gene silencing by inhibition of translation

Across TCGA patient cohorts, RNA activity of the miRNA-mediated gene silencing by inhibition of translation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A28, C9orf139, and NHP2P1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by inhibition of translation activity versus SLC25A28 in LUAD (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SLC25A28 →	-0.235	-0.637	.003	<.001	3	4
LUAD	C9orf139 →	-0.355	-0.848	<.001	<.001	3	3
GBM	NHP2P1 →	-0.460	-0.522	<.001	.001	3	3
GBM	PIP4K2A →	-0.866	-0.585	<.001	.001	3	3
GBM	SOWAHD →	-0.523	-0.447	<.001	<.001	3	3
UCEC	COA6-AS1 →	-0.590	-0.213	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035278 vs SLC25A28 — LUAD

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