miRNA-mediated gene silencing by inhibition of translation

Across TCGA cell cohorts, RNA activity of the miRNA-mediated gene silencing by inhibition of translation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC92, MAPK11, and CTDSP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCDC92 grouped by miRNA-mediated gene silencing by inhibition of translation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CCDC92 →	-1.336	-0.340	<.001	.001	3	4
LUNG_NSCLC_LUAD	MAPK11 →	-1.285	-0.210	<.001	.002	3	4
LARGE_INTESTINE	CTDSP1 →	-0.498	-0.270	.008	.004	3	4
LARGE_INTESTINE	TIGD6 →	-0.622	-0.333	<.001	<.001	3	4
LARGE_INTESTINE	PDK2 →	-1.090	-0.410	.002	.009	3	4
CNS	RNF10 →	-0.366	-0.302	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCDC92 by miRNA-mediated gene silencing by inhibition of translation activity — CNS

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