miRNA-mediated gene silencing by inhibition of translation

Across TCGA cell cohorts, RNA activity of the miRNA-mediated gene silencing by inhibition of translation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYEF2, IFFO2, and CTBS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, miRNA-mediated gene silencing by inhibition of translation activity versus MYEF2 in BONE (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MYEF2 →	+2.163	+0.434	<.001	<.001	3	6
BLOOD_Lymphoma	IFFO2 →	-2.491	-0.181	<.001	.003	3	5
BLOOD_Lymphoma	CTBS →	-1.309	-0.232	<.001	<.001	3	5
BLOOD_Lymphoma	MVP →	-2.488	-0.166	<.001	<.001	3	5
OVARY	SGCB →	-0.969	-0.263	.006	.004	3	5
BLOOD_Lymphoma	NQO1 →	-1.848	-0.149	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035278 vs MYEF2 — BONE

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