Ionotropic glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Ionotropic glutamate receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FLNA_S1084, ASPN, and FLNA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ionotropic glutamate receptor signaling pathway activity versus FLNA_S1084 in OV (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FLNA_S1084 →	-0.581	-0.040	.001	.002	3	7
COAD	ASPN →	-0.847	-0.048	<.001	.001	3	6
COAD	FLNA →	-0.529	-0.041	<.001	<.001	3	6
CCRCC	FLNA_S2128 →	-0.771	-0.057	.002	.001	3	6
BRCA	HSPG2 →	-0.404	-0.051	.001	.001	3	6
COAD	KANK2 →	-0.379	-0.043	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035235 vs FLNA_S1084 — OV

Explore this scatter interactively →