Ionotropic glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Ionotropic glutamate receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK2B, GRIN3A, and BCKDK, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTK2B grouped by Ionotropic glutamate receptor signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PTK2B →	-0.366	-1.482	<.001	.002	3	7
LUNG_NSCLC_LUAD	GRIN3A →	-0.175	-0.823	.001	<.001	3	6
LARGE_INTESTINE	BCKDK →	-0.238	-1.049	.001	.001	3	5
SKIN	GRIN3B →	-0.173	-0.804	.001	.002	3	5
CNS	WNT7A →	-0.273	-1.270	.006	<.001	3	5
SKIN	GRIA1 →	-0.198	-1.117	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTK2B by Ionotropic glutamate receptor signaling pathway activity — BONE

Explore this box plot interactively →