Ionotropic glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Ionotropic glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASB3, KIF3B, and AKAP10, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ionotropic glutamate receptor signaling pathway activity versus ASB3 in SKIN (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ASB3 →	-0.472	-1.429	.002	<.001	3	3
PANCREAS	KIF3B →	-0.988	-0.349	.002	<.001	3	3
OESOPHAGUS	AKAP10 →	-1.343	-0.610	<.001	<.001	3	3
OESOPHAGUS	ASIC1 →	-1.426	-0.504	.002	<.001	3	3
BREAST	ZBTB49 →	-0.553	-0.298	.003	.007	3	3
SKIN	THOC5 →	-0.992	-1.546	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035235 vs ASB3 — SKIN

Explore this scatter interactively →