Tube formation

Across TCGA patient cohorts, RNA activity of the Tube formation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LTBP3, EVL_S369, and CEP170_S466, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tube formation activity versus LTBP3 in HNSC (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LTBP3 →	+0.366	+0.035	<.001	.006	3	7
LSCC	EVL_S369 →	-0.721	-0.038	<.001	<.001	3	6
CCRCC	CEP170_S466 →	+0.888	+0.052	.004	<.001	3	5
OV	PRKCD →	-0.464	-0.050	.002	<.001	2	6
HNSC	ACTL6A →	+0.206	+0.034	<.001	.001	3	5
HNSC	TP53BP1 →	+0.187	+0.030	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035148 vs LTBP3 — HNSC

Explore this scatter interactively →