Tube formation

Across TCGA pan-cancer cohorts, RNA activity of the Tube formation pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 151 member genes.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher Tube formation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

KIRC, HNSC, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.511	0.700	<.001	75	view →
HNSC	DFS	Quartile	IV	0.556	0.268	<.001	66	view →
LIHC	OS	Median	All	0.675	0.841	<.001	65	view →
BRCA	DFS	Quartile	III,IV	0.928	0.707	.001	59	view →
UCS	DFS	Quartile	II,III,IV	0.860	0.166	.001	44	view →
ACC	OS	Tertile	All	0.538	0.960	<.001	38	view →
LUSC	DFS	Quartile	III,IV	0.477	0.785	.001	36	view →
UVM	DFS	Median	II,III,IV	0.808	0.492	.004	35	view →
LGG	DFS	Median	All	0.667	0.799	<.001	34	view →
OV	DFS	Median	IV	0.313	0.553	.003	32	view →
ESCA	OS	Tertile	III,IV	0.749	0.356	.015	22	view →
SARC	OS	Median	All	0.647	0.838	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0035148–KIRC (DFS)

Open the KIRC breakdown →