Tube formation

Across TCGA patient cohorts, RNA activity of the Tube formation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR8078, SPECC1L, and MAPK1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tube formation activity versus MIR8078 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIR8078 →	+0.410	+0.532	.008	.004	3	2
BRCA	SPECC1L →	+0.586	+0.802	.002	.005	3	1
BRCA	MAPK1 →	+0.629	+0.627	<.001	.006	3	1
BRCA	GRK3 →	+0.952	+0.824	<.001	.005	3	1
BRCA	ADNP2 →	+0.494	+0.799	.002	.006	3	1
BRCA	ERBIN →	+0.605	+0.698	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035148 vs MIR8078 — OV

Explore this scatter interactively →