Tube formation

Across TCGA cell cohorts, RNA activity of the Tube formation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX7A2, RTKN, and MRPS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX7A2 grouped by Tube formation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	COX7A2 →	+0.567	+0.190	.001	.002	3	4
OESOPHAGUS	RTKN →	+1.041	+0.255	.006	<.001	3	4
SKIN	MRPS2 →	+0.582	+1.015	.007	.001	3	3
SKIN	CTRL →	+0.482	+0.933	.003	.002	3	3
CNS	BAG2 →	-0.798	-0.687	<.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CENPA →	-1.146	-0.244	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX7A2 by Tube formation activity — OESOPHAGUS

Explore this box plot interactively →