Tube formation

Across TCGA cell cohorts, RNA activity of the Tube formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASA3, F3, and CRTC1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tube formation activity versus RASA3 in BLOOD_Leukemia (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RASA3 →	+1.836	+0.154	<.001	.008	3	6
LIVER	F3 →	+2.822	+0.252	.008	.002	3	6
STOMACH	CRTC1 →	-1.746	-0.369	.002	.003	3	5
STOMACH	ZNF346 →	-1.161	-0.229	.006	.009	3	5
BLOOD_Leukemia	NCF2 →	+2.243	+0.167	<.001	<.001	3	5
BLOOD_Leukemia	CD55 →	+1.441	+0.148	.003	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035148 vs RASA3 — BLOOD_Leukemia

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