Embryonic hindlimb morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic hindlimb morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MED1, TWIST1, and ZBTB9, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MED1 grouped by Embryonic hindlimb morphogenesis-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MED1 →	-0.480	-0.393	<.001	.003	3	10
KIDNEY	TWIST1 →	-0.229	-0.994	.009	.003	3	5
SKIN	ZBTB9 →	-0.106	-0.247	.003	<.001	3	4
STOMACH	MSL3 →	-0.258	-0.546	<.001	<.001	3	4
SOFT_TISSUE	TMEM67 →	+0.199	+0.712	.003	.003	3	3
SOFT_TISSUE	DDX20 →	+0.138	+0.702	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MED1 by Embryonic hindlimb morphogenesis activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →