Embryonic appendage morphogenesis

Across TCGA cell cohorts, RNA activity of the Embryonic appendage morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM214, NEK3, and SETBP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic appendage morphogenesis activity versus TMEM214 in BLOOD_Leukemia (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TMEM214 →	-0.411	-0.986	.006	.006	3	5
BLOOD_Leukemia	NEK3 →	-1.743	-0.799	<.001	.001	3	5
BLOOD_Myeloma	SETBP1 →	+1.916	+1.599	.001	.001	3	4
BLOOD_Leukemia	DESI1 →	-0.568	-0.934	.008	.002	3	4
BLOOD_Leukemia	RAB29 →	-1.220	-1.092	<.001	.002	3	4
BLOOD_Leukemia	RAPGEF5 →	+1.615	+0.956	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035113 vs TMEM214 — BLOOD_Leukemia

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