Behavioral response to nicotine

Across TCGA patient cohorts, RNA activity of the Behavioral response to nicotine pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BTK, COL14A1, and FLNA_S2414, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Behavioral response to nicotine activity versus BTK in BRCA (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BTK →	-0.294	-0.060	.001	<.001	3	5
BRCA	COL14A1 →	-0.530	-0.054	.003	<.001	3	5
GBM	FLNA_S2414 →	-0.953	-0.118	.007	.003	3	4
GBM	GPX8 →	-0.656	-0.073	<.001	<.001	3	4
BRCA	MSRB3 →	-0.608	-0.062	<.001	<.001	3	4
BRCA	TLN1 →	-0.217	-0.064	.004	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035095 vs BTK — BRCA

Explore this scatter interactively →