Behavioral response to nicotine

Across TCGA cell cohorts, RNA activity of the Behavioral response to nicotine pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSU72, APLP1, and ZC3H18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SSU72 grouped by Behavioral response to nicotine-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SSU72 →	-0.318	-1.781	.004	<.001	2	5
BREAST	APLP1 →	+0.110	+1.049	.005	<.001	3	4
SOFT_TISSUE	ZC3H18 →	+0.393	+1.025	.002	.008	3	4
PANCREAS	MFSD11 →	+0.256	+1.488	.003	.006	2	4
LUNG_NSCLC_LUAD	HOXB7 →	+0.204	+0.834	.002	.005	3	3
OVARY	NTRK2 →	+0.119	+0.993	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SSU72 by Behavioral response to nicotine activity — OVARY

Explore this box plot interactively →