Negative regulation of monoatomic ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Negative regulation of monoatomic ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBOAT1, CORO1C, and EPHA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of monoatomic ion transmembrane transport activity versus MBOAT1 in OVARY (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MBOAT1 →	-1.513	-0.249	.001	<.001	3	5
BREAST	CORO1C →	+0.953	+0.217	.004	.001	3	5
BREAST	EPHA1 →	-2.335	-0.272	<.001	.002	3	5
LARGE_INTESTINE	MFF →	+0.337	+0.179	.002	.007	3	5
LARGE_INTESTINE	MT-CO1 →	-0.656	-0.218	.006	<.001	3	5
OVARY	LMNB2 →	+1.092	+0.269	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034766 vs MBOAT1 — OVARY

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