Negative regulation of monoatomic ion transmembrane transport

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of monoatomic ion transmembrane transport pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 97 member genes.

The strongest signal is observed in small cell lung cancer (SCLC), where higher Negative regulation of monoatomic ion transmembrane transport pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as ACC and KIRC, show the opposite pattern, with higher activity associated with better survival.

SCLC, ACC, and KIRC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Quartile	All	0.288	0.656	<.001	71	view →
ACC	DFS	Median	All	0.784	0.367	.001	69	view →
KIRC	DFS	Median	All	0.754	0.525	.001	37	view →
KIRP	OS	Median	II,III,IV	0.169	0.764	.007	36	view →
LGG	DFS	Quartile	All	0.668	0.892	<.001	30	view →
COAD	OS	Median	IV	0.653	0.340	.006	27	view →
ESCA	OS	Tertile	IV	0.243	0.743	.024	23	view →
HNSC	DFS	Median	IV	0.629	0.467	.001	20	view →
LUSC	OS	Tertile	IV	0.001	0.651	.025	18	view →
GBM	DFS	Median	All	0.161	0.339	.007	15	view →
DLBC	OS	Tertile	All	0.490	1.000	.009	13	view →
LUAD	DFS	Median	IV	0.753	0.332	.034	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0034766–SCLC (OS)

Open the SCLC breakdown →