Regulation of iron ion transport

Across TCGA patient cohorts, RNA activity of the Regulation of iron ion transport pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCB, RPL15P4, and SHANK2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of iron ion transport activity versus PRKCB in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKCB →	-0.668	-0.748	<.001	.001	3	5
CCRCC	RPL15P4 →	-0.142	-0.527	.001	.005	3	3
HNSC	SHANK2 →	+1.044	+0.750	<.001	<.001	3	3
HNSC	TRAJ53 →	-0.682	-0.426	.001	.006	3	3
HNSC	DNAJA1P6 →	+0.524	+0.440	.001	.005	3	3
HNSC	CELF2 →	-0.592	-0.569	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034756 vs PRKCB — BRCA

Explore this scatter interactively →