Regulation of iron ion transport

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of iron ion transport pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 8 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Regulation of iron ion transport pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LGG and KICH, show the opposite pattern, with higher activity associated with better survival.

LGG, CESC, and KICH are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.817	0.663	<.001	54	view →
CESC	OS	Median	All	0.479	0.668	<.001	48	view →
KICH	OS	Quartile	III,IV	0.885	0.178	.006	48	view →
MESO	OS	Tertile	II,III,IV	0.467	0.304	.024	30	view →
SCLC	DFS	Tertile	II,III,IV	0.976	0.253	.006	28	view →
ACC	DFS	Median	IV	0.495	0.066	.001	27	view →
KIRP	DFS	Quartile	All	0.914	0.783	.010	25	view →
SKCM	OS	Median	IV	0.376	0.808	.008	21	view →
COAD	DFS	Median	II,III,IV	0.718	0.356	.004	17	view →
UVM	DFS	Tertile	All	0.410	0.640	.014	17	view →
PRAD	DFS	Quartile	All	0.955	0.839	.001	16	view →
LIHC	DFS	Median	All	0.483	0.390	.005	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0034756–LGG (DFS)

Open the LGG breakdown →