Regulation of iron ion transport

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of iron ion transport pathway differs between tumor and matched normal tissue in 15 of the 18 cancer types tested.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as LIHC and KIRP, show the opposite pattern, with lower activity in tumor tissue.

LIHC, KIRP, and HNSC show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
LIHC	Female	All	−0.064	<.001	9	view →
KIRP	All	II,III,IV	−0.062	<.001	9	view →
HNSC	All	IV	−0.062	<.001	9	view →
KIRC	Male	III,IV	−0.050	<.001	9	view →
THCA	All	II,III,IV	+0.043	<.001	9	view →
STAD	All	III,IV	−0.101	<.001	6	view →
BRCA	All	III,IV	−0.087	<.001	6	view →
CHOL	Female	All	−0.240	<.001	5	view →
COAD	All	III,IV	−0.034	.006	5	view →
UCEC	All	All	−0.042	.020	2	view →
LUSC	All	All	−0.034	<.001	2	view →
PRAD	All	All	−0.026	.007	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 12 strongest of 15 lineages.

GO:0034756–LIHC

Open the LIHC breakdown →