Regulation of iron ion transport

Across TCGA cell cohorts, RNA activity of the Regulation of iron ion transport pathway is significantly associated with the protein abundance of multiple proteins, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are B2M, HLA-C, and ITPR3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of iron ion transport activity versus B2M in BREAST (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	B2M →	+2.370	+1.467	<.001	<.001	3	8
BREAST	HLA-C →	+3.203	+1.623	<.001	<.001	3	4
BREAST	ITPR3 →	+1.534	+1.516	<.001	<.001	3	4
PANCREAS	LCN2 →	+3.798	+0.415	<.001	<.001	3	4
STOMACH	PSMD5 →	-1.069	-1.395	.001	<.001	3	3
LARGE_INTESTINE	GNPNAT1 →	-1.655	-1.429	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034756 vs B2M — BREAST

Explore this scatter interactively →