Cellular response to heat

Across TCGA patient cohorts, RNA activity of the Cellular response to heat pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU1-88P, RNU6-387P, and ASB16-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to heat activity versus RNU1-88P in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU1-88P →	+0.341	+0.158	.001	.003	3	4
GBM	RNU6-387P →	+0.463	+0.118	.007	.002	3	3
GBM	ASB16-AS1 →	+0.451	+0.197	<.001	<.001	3	3
CCRCC	TWNK →	+0.263	+0.160	.006	.002	3	3
CCRCC	EIF3LP3 →	+0.241	+0.174	.008	<.001	3	3
OV	COX7A1 →	-0.677	-0.125	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034605 vs RNU1-88P — BRCA

Explore this scatter interactively →