piRNA processing

Across TCGA cell cohorts, RNA activity of the piRNA processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAHD1, RPS16, and SAMD9L, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, piRNA processing activity versus FAHD1 in BLOOD_Lymphoma (Pearson r = -0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FAHD1 →	-1.170	-1.939	.007	<.001	3	2
BLOOD_Lymphoma	RPS16 →	+0.922	+1.797	<.001	<.001	3	2
BLOOD_Lymphoma	SAMD9L →	-2.738	-1.386	.004	.001	3	2
BLOOD_Lymphoma	ZNF688 →	-1.210	-1.896	.004	.001	3	2
LUNG_SCLC	NANOG →	+0.151	+1.807	<.001	<.001	3	1
LUNG_SCLC	VPS25 →	+1.134	+2.036	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034587 vs FAHD1 — BLOOD_Lymphoma

Explore this scatter interactively →