Protein localization to phagophore assembly site

Across TCGA cell cohorts, RNA activity of the Protein localization to phagophore assembly site pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMC1, NOL12, and SHQ1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to phagophore assembly site activity versus TMC1 in OVARY (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TMC1 →	+0.605	+1.172	.001	.002	3	5
BLOOD_Lymphoma	NOL12 →	-0.730	-0.257	.001	.004	2	5
KIDNEY	SHQ1 →	-1.094	-0.385	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	RPL23 →	-0.965	-1.260	.001	.005	3	4
BONE	EARS2 →	-1.280	-1.887	<.001	.004	3	4
LUNG_SCLC	SDC4 →	+2.270	+0.693	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034497 vs TMC1 — OVARY

Explore this scatter interactively →