Protein localization to phagophore assembly site

Across TCGA pan-cancer cohorts, RNA activity of the Protein localization to phagophore assembly site pathway is associated with patient survival in 16 of 34 cancer lineages. Pathway activity is summarized from the expression of its 16 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Protein localization to phagophore assembly site pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and BRCA, show the opposite pattern, with higher activity associated with better survival.

UCEC, LGG, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.613	0.821	.002	62	view →
LGG	OS	Quartile	All	0.682	0.844	<.001	39	view →
ACC	DFS	Quartile	All	0.356	0.874	<.001	33	view →
KIRC	DFS	Median	All	0.696	0.565	.002	32	view →
BRCA	DFS	Quartile	III,IV	0.953	0.789	.002	28	view →
KIRP	DFS	Median	All	1.000	0.784	.001	26	view →
HNSC	OS	Tertile	III,IV	0.188	0.576	<.001	22	view →
ESCA	OS	Quartile	III,IV	0.731	0.297	.006	14	view →
SCLC	DFS	Median	IV	0.630	0.164	.022	14	view →
DLBC	DFS	Quartile	III,IV	0.074	0.984	.017	12	view →
BLCA	DFS	Median	All	0.468	0.669	.007	6	view →
COAD	DFS	Median	All	0.778	0.620	.021	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GO:0034497–UCEC (DFS)

Open the UCEC breakdown →