Plasma lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Plasma lipoprotein particle clearance pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are APBB1IP, HCK, and PLCB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Plasma lipoprotein particle clearance activity versus APBB1IP in GBM (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	APBB1IP →	+0.561	+0.054	<.001	<.001	3	7
GBM	HCK →	+0.510	+0.034	<.001	<.001	3	6
GBM	PLCB2 →	+0.506	+0.058	<.001	<.001	3	6
LSCC	WDFY4 →	+0.330	+0.047	<.001	<.001	3	6
LSCC	CAP1 →	+0.232	+0.047	<.001	<.001	3	6
GBM	DEF6 →	+0.549	+0.053	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0034381 vs APBB1IP — GBM

Explore this scatter interactively →